Belda W, dos Santos Júnior M F, Fagundes L J, Siqueira L F, Lombardi C, Francisco W
Sex Transm Dis. 1984 Oct-Dec;11(4 Suppl):420-2. doi: 10.1097/00007435-198410001-00029.
Eighty-two male patients with acute gonococcal urethritis were given a single oral dose of 2.5 g of granulated thiamphenicol dissolved in water, and the results of treatment were evaluated after 48-72 hr and one week. Of the 76 patients who returned for the first follow-up examination, 75 (98.7%) no longer had Neisseria gonorrhoeae in urethral smears or cultures. Five of these patients did not return for the second follow-up examination, and another four who did return were found to be reinfected as a result of reexposure. Of the remaining 67 patients, 66 (98.5%) no longer had N. gonorrhoeae in urethral smears or cultures. Thus, the overall success rate among the 71 patients who completed the study (with the four cases of reinfection considered instances of failure of therapy) was 93%. The ease of administration, absence of adverse reactions, low failure rate, and low incidence of residual urethral secretions (4.5%) justify the use of thiamphenicol as the drug of choice for the treatment of acute gonococcal urethritis in male patients.
82例急性淋菌性尿道炎男性患者单次口服溶于水的2.5g颗粒状甲砜霉素，48 - 72小时及1周后评估治疗结果。76例返回进行首次随访检查的患者中，75例（98.7%）尿道涂片或培养不再有淋病奈瑟菌。其中5例患者未返回进行第二次随访检查，另外4例返回的患者因再次接触而被重新感染。其余67例患者中，66例（98.5%）尿道涂片或培养不再有淋病奈瑟菌。因此，在完成研究的71例患者中（将4例重新感染视为治疗失败的病例），总体成功率为93%。给药方便、无不良反应、失败率低以及残留尿道分泌物发生率低（4.5%）证明甲砜霉素可作为男性急性淋菌性尿道炎治疗的首选药物。
