5α-二氢皮质类固醇对大鼠肝脏糖异生酶的影响。

Effect of 5 alpha-dihydrocorticoids on enzymes of gluconeogenesis in rat liver.

作者信息

Golf S W, Bepperling F, Graef V

出版信息

Steroids. 1984 Jan;43(1):85-91. doi: 10.1016/0039-128x(84)90060-6.

Abstract

5 alpha-Dihydrocortisol (11 beta, 17, 21-trihydroxy-5 alpha-pregnane-3,20-dione), 5 alpha-dihydrocorticosterone (11 beta, 21-dihydroxy-5 alpha-pregnane-3,20-dione) as well as cortisol (11 beta, 17, 21-trihydroxy-4-pregnene-3,20-dione) and corticosterone (11 beta, 21-dihydroxy-4-pregnene-3,20-dione) were administered for seven days to male rats. Blood glucose increased in cortisol- and corticosterone-treated rats and blood insulin decreased after 5 alpha-dihydrocorticosteroid treatment. In the liver, total protein was elevated after cortisol, corticosterone and 5 alpha-dihydrocorticosterone application. Phosphoenolpyruvate carboxykinase and fructose-1,6-diphosphatase activities in liver were significantly lowered after treatment with 5 alpha-dihydrocortisol and 5 alpha-dihydrocorticosterone.

摘要

给雄性大鼠连续七天注射5α-双氢皮质醇（11β,17,21-三羟基-5α-孕烷-3,20-二酮）、5α-双氢皮质酮（11β,21-二羟基-5α-孕烷-3,20-二酮）以及皮质醇（11β,17,21-三羟基-4-孕烯-3,20-二酮）和皮质酮（11β,21-二羟基-4-孕烯-3,20-二酮）。经皮质醇和皮质酮处理的大鼠血糖升高，而经5α-双氢皮质类固醇处理后血胰岛素降低。在肝脏中，应用皮质醇、皮质酮和5α-双氢皮质酮后总蛋白升高。用5α-双氢皮质醇和5α-双氢皮质酮处理后，肝脏中的磷酸烯醇丙酮酸羧激酶和果糖-1,6-二磷酸酶活性显著降低。