Stengel R, Stricker R, Schöpf E
Z Hautkr. 1984 Dec 1;59(23):1620-2.
On account of clinical experience as well as experimental findings, we noticed subsiding anti-inflammatory and antiproliferative effects of topical corticosteroids after regularly repeated application. Following four-day's oral therapy with methylprednisolone 40 mg daily, the pyrexal erythema test did not reveal any decrease of anti-inflammatory effect in six volunteers. The efficacy of this therapy was similar to that of occlusive topical therapy with 0.25% desoxymethasone ointment. The anti-inflammatory effect of systemic steroid treatment could even be slightly increased by additional topical steroid therapy.
基于临床经验以及实验结果，我们注意到局部用皮质类固醇激素在定期重复使用后其抗炎和抗增殖作用会逐渐减弱。在6名志愿者中，每日口服40mg甲泼尼龙进行为期4天的治疗后，热红斑试验未显示出抗炎作用有任何降低。该疗法的疗效与用0.25%地索奈德软膏进行封包局部治疗的疗效相似。额外的局部类固醇激素治疗甚至可能会使全身性类固醇治疗的抗炎作用略有增强。
