Fundamental physical properties of lymph formation are described in connection with the permeability of the terminal vascular system (Ludwig Stahling's hypothesis). In view of the current image of this system, as far as it is derived from the isogravimetric model, this can no longer be considered generally valid. Above all the recent vital microscopic studies clearly show that the venous system is of special importance for lymph formation as it possesses special permeability properties and is enclosed by a system of paravascular interstices. They form a protein pool in the tissue releasing a colloid-osmotic energy for the lymph motion. The lymph is drained away by means of "low resistance pathway" correlated with the elastic fiber system and by slow resistance pathways filled with ground substance to reach the efferent lymphatic vessels via an open communication system.
淋巴形成的基本物理特性是结合终末血管系统的通透性来描述的（路德维希·施塔林假说）。鉴于该系统目前基于等重模型得出的认知，这一假说已不再被认为普遍适用。尤其是最近的活体显微镜研究清楚地表明，静脉系统对淋巴形成具有特殊重要性，因为它具有特殊的通透性特性，并且被血管旁间隙系统所包围。它们在组织中形成一个蛋白质池，为淋巴流动释放胶体渗透能。淋巴通过与弹性纤维系统相关的“低阻力途径”以及充满基质的缓慢阻力途径排出，通过开放的连通系统到达输出淋巴管。
