Iakovleva N V, Kristalinskaia E A
Zh Mikrobiol Epidemiol Immunobiol. 1984 Oct(10):69-71.
The possibility of the active multiplication of S. pneumoniae (serotypes 1, 3, 6 and 19) in the allantoic cavity of chick embryos has been demonstrated. This multiplication is accompanied by the development of characteristic changes whose intensity and time of manifestation have been found to depend on the infective dose and the age of the embryo. The accumulation of S. pneumoniae in the allantoic cavity of chick embryos in the absence of visible changes in the biological properties of the infective agent after 5 successive subcultures makes it possible to recommend chick embryos as a model for the study of experimental pneumococcal infection.
已证实肺炎链球菌（血清型1、3、6和19）在鸡胚尿囊腔中具有活跃增殖的可能性。这种增殖伴随着特征性变化的出现，其强度和表现时间取决于感染剂量和胚胎的年龄。在连续5次传代后，感染因子的生物学特性无明显变化的情况下，肺炎链球菌在鸡胚尿囊腔中的积累使得推荐将鸡胚作为研究实验性肺炎球菌感染的模型成为可能。
