高压氧治疗的自发性高血压大鼠肾上腺肾上腺素和去甲肾上腺素增加。

Increased adrenal epinephrine and norepinephrine in spontaneously hypertensive rats treated with hyperbaric oxygen.

作者信息

Nakada T, Koike H, Katayama T, Watanabe H, Yamori Y

出版信息

Hinyokika Kiyo. 1984 Oct;30(10):1357-66.

Abstract

Adrenal catecholamines were determined in Wistar Kyoto rats (WKY), and stroke-prone and stroke-resistant spontaneously hypertensive rats (SHRSP, SHR) treated with hyperbaric oxygen for 90 minutes daily from 6 to 13 weeks of age. The animals were divided into 5 groups. Group I (control group), was handled under the same conditions as pressure-treated groups II and III, but with ambient oxygen pressure and concentration. Group II (pressure-control group), was treated with 2 atmospheric absolute pressures (ATA) of air without any oxygen provided. Group III (high-oxygen group), was exposed to 2 ATA under the environment of air saturating oxygen. Group IV (antihypertensive group), was treated with hydralazine. Group V (adrenalectomized group), was given 1% NaCl solution and bilateral adrenalectomy. The average contents of adrenal norepinephrine of SHR and of SHRSP in Group I were greater (p less than 0.05-p less than 0.001) than those of the WKY in Group I. A similar tendency was also observed for the content of adrenal epinephrine. The average concentrations of adrenal epinephrine and norepinephrine of SHR and SHRSP in Group II and III were significantly (p less than 0.05-p less than 0.001) greater than those of the respective rats in Group I, but no significant differences were noted in the blood pressure between pressure-treated groups (II, III) and the control group (I). Adrenalectomized SHR, SHRSP and WKY rats (Group V) had similar blood pressure levels as the control rats (Group I). The development of hypertension in SHR and SHRSP was effectively suppressed by the treatment with hydralazine, which, however failed to reduce concentrations of adrenal epinephrine and norepinephrine in these rats. These results indicate that increased adrenomedullary function in SHR and SHRSP is further enhanced by hyperbaric oxygenation treatment, but that high concentrations of adrenal catecholamines are not required for the pathogenesis of spontaneous hypertension of these animals at this age.

摘要

对Wistar Kyoto大鼠（WKY）以及从6至13周龄开始每天接受90分钟高压氧治疗的易中风和抗中风自发性高血压大鼠（SHRSP、SHR）的肾上腺儿茶酚胺进行了测定。将动物分为5组。第一组（对照组），在与压力处理组II和III相同的条件下处理，但采用环境氧压和浓度。第二组（压力对照组），用2个绝对大气压（ATA）的空气进行处理，不提供任何氧气。第三组（高氧组），在空气饱和氧气的环境下暴露于2 ATA。第四组（抗高血压组），用肼屈嗪进行处理。第五组（肾上腺切除组），给予1%氯化钠溶液并进行双侧肾上腺切除术。第一组中SHR和SHRSP的肾上腺去甲肾上腺素平均含量高于（p<0.05 - p<0.001）第一组中的WKY。肾上腺肾上腺素含量也观察到类似趋势。第二组和第三组中SHR和SHRSP的肾上腺肾上腺素和去甲肾上腺素平均浓度显著高于（p<0.05 - p<0.001）第一组中的相应大鼠，但压力处理组（II、III）与对照组（I）之间的血压无显著差异。肾上腺切除的SHR、SHRSP和WKY大鼠（第五组）的血压水平与对照大鼠（第一组）相似。肼屈嗪治疗有效抑制了SHR和SHRSP高血压的发展，然而未能降低这些大鼠肾上腺肾上腺素和去甲肾上腺素的浓度。这些结果表明，高压氧治疗进一步增强了SHR和SHRSP中肾上腺髓质功能的增强，但在这个年龄段，这些动物自发性高血压的发病机制并不需要高浓度的肾上腺儿茶酚胺。