Ellenberger M A, Kaeberle M L, Roth J A
Am J Vet Res. 1984 Nov;45(11):2428-30.
An enzyme-linked immunosorbent assay was developed to test equine serum for the presence of antibodies to Rhodococcus (Corynebacterium) equi. Experimental ponies had no detectable antibody to R equi before exposure to the bacterium. After experimental inoculation, animals in groups that received live R equi subcutaneously or intranasally/intratracheally developed high titers to R equi. Noninoculated controls remained seronegative. Serum was also collected from horses of various ages that were naturally exposed to R equi. There was a wide range of anti-R equi titers in these horses. Because experimentally infected horses seroconverted when some naturally infected foals did not seroconvert, the function of antibody in resistance to R equi infection remains unknown.
开发了一种酶联免疫吸附试验，用于检测马血清中是否存在抗马红球菌（马棒状杆菌）抗体。实验小马在接触该细菌之前未检测到抗马红球菌抗体。实验接种后，经皮下或经鼻/气管内接种活马红球菌的组中的动物产生了高滴度的抗马红球菌抗体。未接种的对照组仍为血清阴性。还从自然接触马红球菌的不同年龄的马身上采集了血清。这些马的抗马红球菌抗体滴度范围很广。由于实验感染的马出现血清转化，而一些自然感染的幼驹未出现血清转化，因此抗体在抵抗马红球菌感染中的作用仍然未知。
