Navarro M, Espinosa L, de las Heras J A, García Meseguer M C, Peña M A, Larrauri M
An Esp Pediatr. 1984 Oct 31;21(6):564-72.
A series of 129 children with urinary infection during the first 120 days of life, were followed-up for periods ranging from to 1 to 16 years (means = 4 1/12 year). They have been separated in two groups, depending on urocystographic findings: (I) with mild lesions and/or reflux (99 cases) and (II) with obstructive uropathy (30 cases). All the patients in group II and those with reflux of grade IV received surgical treatment. The remaining ones received chemoprophylaxis. During the follow-up, all grade I refluxes disappeared, and so did 86% of grade II and 58% of grade III. Pyelonephritic scars are present in 34% of those kidneys with grade III reflux, 56% of grade IV and 88% of those of the group II. Permanent alteration of renal function was found almost exclusively in patients with grade IV reflux or obstructive anomalies bearing no relation with the number of recurrences of infection during the follow-up.
对129例出生后120天内患泌尿道感染的儿童进行了随访，随访时间为1至16年（平均4又1/12年）。根据膀胱尿道造影结果，他们被分为两组：（I）轻度病变和/或反流组（99例）和（II）梗阻性尿路病组（30例）。第二组的所有患者以及IV级反流患者均接受了手术治疗。其余患者接受化学预防。在随访期间，所有I级反流均消失，II级反流的86%和III级反流的58%也消失了。III级反流的肾脏中34%存在肾盂肾炎瘢痕，IV级为56%，第二组为88%。几乎仅在IV级反流或梗阻性异常的患者中发现肾功能永久性改变，这与随访期间感染复发的次数无关。
