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[大鼠被鼠类圆线虫寄生、雌性性激素与血液皮质酮之间的关系]

[Relations between parasitism of the rat by Strongyloides ratti, female sex hormones and blood corticosterone].

作者信息

Bailenger J, Cabannes A, Lacassie-Josuat I

出版信息

Ann Parasitol Hum Comp. 1984;59(6):619-33.

PMID:6524825
Abstract

Situated under strict conditions in order to try to limit experimental aggravation and to respect the accomplishment of an endocrine balance, the experiments carried out study the influence on parasitism by Strongyloides ratti of ovariectomie and the treatments, of female rats castrated or not, by oestradiol, hexoestrol, diethylstilboestrol, progesterone, mestranol, chlormadinone association. Similarly, adrenal cortex reactions (corticosterone) to the treatment and parasitism are recorded. The analysis of the results lead to the thought that the glucocorticosteroid function of adrenal cortex could be one of the relays between gonades and the development of parasitism (intensity, removal of parasites).

摘要

实验在严格条件下进行,旨在限制实验干扰并维持内分泌平衡,研究卵巢切除以及雌二醇、己烯雌酚、己烷雌酚、孕酮、炔雌醇甲醚、氯地孕酮联合用药对已阉割或未阉割雌性大鼠感染鼠类圆线虫的影响。同样,记录肾上腺皮质对治疗和寄生虫感染的反应(皮质酮)。结果分析表明,肾上腺皮质的糖皮质激素功能可能是性腺与寄生虫感染发展(强度、寄生虫清除)之间的关联环节之一。

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