Fichna P, Malendowicz L K
Endokrinologie. 1980 Mar;75(2):173-86.
Studies on the effects of progesterone on rat adrenal cortex were performed on two age groups of intact or ovariectomized female rats. Ovariectomy was performed on animals weighing 150-170 g and autopsies were carried out 6 weeks and 8.5 months after surgery (4- and 11-month-old animals). 12 days before autopsy part of the animals were treated with progesterone at a daily dose of 5 mg per rat, the others received a single injection of depot-estradiol or jointly with progesterone and estradiol. Intact female rats of a corresponding age were treated with progesterone or vehicle only. In younger intact female rats progesterone lowers the relative adrenal weight and corticosterone output by whole adrenal homogenates. In older rats despite the lowering in absolute and relative adrenal weights there were no changes in corticosterone output. In ovariectomized rats of both age groups progesterone had no marked effects on studied parameters while estradiol resulted in an increase in adrenal weights and corticosterone output. Part of the changes evoked by estradiol were prevented by concomitant progesterone administration. The above described changes were accompanied by morphologic alterations. Performed studies show that progesterone effects on the rat adrenal cortex are modified by the ovaries and depend on the age of animals.
在完整或卵巢切除的雌性大鼠的两个年龄组上进行了孕酮对大鼠肾上腺皮质作用的研究。对体重150 - 170克的动物进行卵巢切除，并在手术后6周和8.5个月（4个月和11个月大的动物）进行尸检。在尸检前12天，部分动物每天以每只大鼠5毫克的剂量接受孕酮治疗，其他动物接受一次长效雌二醇注射或同时接受孕酮和雌二醇注射。相应年龄的完整雌性大鼠仅用孕酮或赋形剂治疗。在较年轻的完整雌性大鼠中，孕酮降低了相对肾上腺重量和整个肾上腺匀浆的皮质酮产量。在老年大鼠中，尽管绝对和相对肾上腺重量降低，但皮质酮产量没有变化。在两个年龄组的卵巢切除大鼠中，孕酮对所研究的参数没有显著影响，而雌二醇导致肾上腺重量和皮质酮产量增加。同时给予孕酮可预防部分由雌二醇引起的变化。上述变化伴有形态学改变。所进行的研究表明，孕酮对大鼠肾上腺皮质的作用受卵巢影响，并取决于动物的年龄。
