Ul'ianova L A, Tarasova V E, Bazhanov V S, Iudina O I, Gol'dberg L E
Antibiotiki. 1984 Nov;29(11):861-6.
Antitumor activity of doxorubicin made in the USSR was studied on mice in respect to three transplantable tumors (lymphadenosis NK/LI, sarcoma 37 and Ehrlich's carcinoma) and hemocytoblastosis La. Doxorubicin injected intravenously 4 times was shown to be highly active against the above ascites tumors. The highest inhibitory effect of doxorubicin was observed in respect to the development of Ehrlich's carcinoma. By the selectivity of the therapeutic effect on this tumor it was superior to rubomycin and carminomycin. A high antileukemic activity of doxorubicin in respect to hemocytoblastosis La was shown. In experiments with this leukemia, intravenous injection of doxorubicin provided a higher efficacy than intraperitoneal injection. When used intravenously in the doses equivalent by their toxicity doxorubicin was inferior to rubomycin in terms of the therapeutic effect on leukemia La. However, on intraperitoneal injection of the drugs rubomycin showed no such advantage. Doxorubicin made in the USSR did not differ by its antitumor activity from the analogous foreign drug.
对苏联产阿霉素的抗肿瘤活性进行了研究，研究对象为小鼠的三种可移植肿瘤（淋巴腺瘤NK/LI、肉瘤37和艾氏癌）以及白血病La。静脉注射4次阿霉素对上述腹水肿瘤显示出高活性。阿霉素对艾氏癌的发展具有最高抑制作用。就对该肿瘤治疗效果的选择性而言，它优于柔红霉素和洋红霉素。阿霉素对白血病La显示出高抗白血病活性。在该白血病实验中，静脉注射阿霉素比腹腔注射疗效更高。当以毒性相当的剂量静脉使用时，阿霉素对白血病La的治疗效果不如柔红霉素。然而，腹腔注射药物时，柔红霉素没有这种优势。苏联产阿霉素的抗肿瘤活性与国外同类药物没有差异。
