Volkova L M, D'iachkovskaia R F, Konovalova N P
Antibiotiki. 1979 Apr;24(4):300-3.
Antitumor efficiency of combined therapy of experimental tumors with diazan and antibiotics was studied. The experiments were performed with leukosis La and P-388 and Walker carcinosarcoma. The kinetic regularities of the tumor process were used in planning regimens of the combined therapy. It was found that the combined use of diazan with antitumor antibiotics of the anthracyclin series increased the therapy efficacy. Therapeutic synergism of the drugs was noted which was evident from a significant increase in the average life rate and recovery of a part of the animals.
研究了二氮嗪与抗生素联合治疗实验性肿瘤的抗肿瘤效果。实验选用了白血病La、P - 388和沃克癌肉瘤。在制定联合治疗方案时利用了肿瘤进程的动力学规律。发现二氮嗪与蒽环类抗肿瘤抗生素联合使用可提高治疗效果。注意到药物的治疗协同作用，这从动物平均存活率的显著提高和部分动物的康复中明显体现出来。
