当地药店配制的维生素A制剂的微生物污染情况及其对酵母菌和霉菌的保存情况。
Microbial contamination of a vitamin A formulation, prepared in local pharmacies, and its preservation against yeasts and moulds.
作者信息
van Doorne H, Scheffers W A, Hadiutomo M, van den Bosch E
出版信息
Antonie Van Leeuwenhoek. 1984;50(4):405-16. doi: 10.1007/BF00394655.
PMID:6524914
Abstract
The microbial contamination of 44 samples of a vitamin A preparation in sucrose syrup was investigated. The contaminants were almost exclusively yeasts and moulds. Microbiological and physicochemical studies showed that sorbic acid was the preservative of choice for this formulation. The results are discussed with respect to the preservation of non-sterile pharmaceuticals.
摘要
对44份蔗糖糖浆中维生素A制剂样本的微生物污染情况进行了调查。污染物几乎全是酵母和霉菌。微生物学和物理化学研究表明，山梨酸是该制剂的首选防腐剂。结合非无菌药品的保存对结果进行了讨论。
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