Vasopressin effects on food-rewarded learning tasks might be due to its action on carbohydrate/lipid metabolism, not memory.

Vasopressin (VP) has been implicated in memory processes on the basis of effects observed in aversively motivated learning situations. Therefore researchers have tried to confirm this role by using food-motivated learning tasks. However, the well-established physiological influences of VP on carbohydrate and lipid metabolism were not taken into consideration. At various times following administration, VP might act as a feeding stimulant or as a satiating agent. Experimental designs should allow for these effects when food-rewarded learning paradigms are used to determine whether VP acts on memory.