Gyarmati S, Földes J, Korányi L, Knoll B, Knoll J
Physiol Behav. 1985 Feb;34(2):167-70. doi: 10.1016/0031-9384(85)90100-3.
The effect of satietin and amphetamine on the carbohydrate metabolism of free fed and food deprived rats was studied. Rats deprived of food for 96 hours maintained normal glucose and glucagon blood levels but the blood concentration of insulin dropped from 232.02 +/- 23.93 to 12.48 +/- 0.71 pmol/l. Amphetamine (500 micrograms/animal, intracerebroventricularly) left in normally fed rats the blood concentration of glucose, insulin and glucagon unchanged. The same treatment, however, increased the insulin concentration in the blood of food deprived rats from 11.37 +/- 4.43 to 73.47 +/- 8.29 pmol/l. Glucose and glucagon, as well as insulin levels remained unchanged in both normally fed and food deprived rats when treated with satietin (20 micrograms/rat, intracerebroventricularly). It was concluded that the anorectic effect of satietin is unrelated to carbohydrate metabolism.
研究了饱腹感素和苯丙胺对自由进食及禁食大鼠碳水化合物代谢的影响。禁食96小时的大鼠血糖和胰高血糖素水平维持正常，但胰岛素血浓度从232.02±23.93皮摩尔/升降至12.48±0.71皮摩尔/升。苯丙胺（500微克/只，脑室内注射）对正常进食大鼠的血糖、胰岛素和胰高血糖素血浓度无影响。然而，同样的处理使禁食大鼠的胰岛素血浓度从11.37±4.43皮摩尔/升升至73.47±8.29皮摩尔/升。用饱腹感素（20微克/只，脑室内注射）处理后，正常进食和禁食大鼠的葡萄糖、胰高血糖素以及胰岛素水平均保持不变。得出的结论是，饱腹感素的厌食作用与碳水化合物代谢无关。
