Gronski P, Seiler F R
Behring Inst Mitt. 1984 Nov(76):15-28.
Theoretical predictions from a simple theory for a homogeneous system with respect to some fundamental functional relations between amount of precipitate or extent of turbidity, initial antigen (Ag) respectively antibody (Ab) concentration, and solubility of immune complexes (ICs) are discussed in comparison with experimental results in a heterogeneous system. Experiments were performed with the aim to render possible and intuitive picture of the relationships considering different aspects. It was found that the theory derived from the equilibrium state of the reaction is also able to describe the non-equilibrium state in a qualitatively correct manner. The influence of Ab affinity on precipitation is discussed. Moreover, it is shown that the theory developed by Pauling et al. in the 1940's although too simple in several details, does, however, consider the most important basic principles of more extensive theories developed by other authors. Precisely because of its simplicity, this model may be a useful help in the discussion of precipitate formation on a molecular level.
本文讨论了一个关于均匀系统的简单理论对沉淀物量或浊度、初始抗原（Ag）或抗体（Ab）浓度以及免疫复合物（ICs）溶解度之间某些基本函数关系的理论预测，并与非均匀系统中的实验结果进行了比较。进行实验的目的是从不同方面呈现这些关系，使其变得直观易懂。研究发现，从反应平衡态推导出来的理论也能够以定性正确的方式描述非平衡态。文中讨论了Ab亲和力对沉淀的影响。此外，研究表明，鲍林等人在20世纪40年代提出的理论虽然在一些细节上过于简单，但确实考虑到了其他作者所提出的更广泛理论的最重要基本原理。正是由于其简单性，该模型在分子水平上讨论沉淀物形成时可能会有所帮助。
