氯丙嗪的膜溶解性。吸湿解吸法和离心法得出的结果相当。
Membrane solubility of chlorpromazine. Hygroscopic desorption and centrifugation methods yield comparable results.
作者信息
Luxnat M, Müller H J, Galla H J
出版信息
Biochem J. 1984 Dec 15;224(3):1023-6. doi: 10.1042/bj2241023.
Abstract
Binding of the positively charged drug chlorpromazine to artificial and erythrocyte bilayer membranes was investigated by the filtration method called hygroscopic desorption [Conrad & Singer (1979) Proc. Natl. Acad. Sci. U.S.A. 76, 5202-5206] and by the conventional centrifugation method. Only minor differences in the partition coefficients were observed using the two methods. Our finding is not consistent with the observation of Conrad & Singer that amphipaths are completely excluded from biological membranes. However, the partition coefficient is dependent on membrane composition, which means dependent on the physical properties of a membrane.
摘要
通过名为吸湿解吸的过滤方法[康拉德和辛格（1979年），《美国国家科学院院刊》76卷，5202 - 5206页]以及传统的离心方法，研究了带正电荷的药物氯丙嗪与人工双层膜和红细胞双层膜的结合情况。使用这两种方法观察到的分配系数只有微小差异。我们的发现与康拉德和辛格的观察结果不一致，他们认为两亲分子完全被排除在生物膜之外。然而，分配系数取决于膜的组成，这意味着取决于膜的物理性质。
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