三磷酸肌醇诱导通透化的瑞士小鼠3T3细胞释放钙的特异性
Specificity of inositol trisphosphate-induced calcium release from permeabilized Swiss-mouse 3T3 cells.
作者信息
Irvine R F, Brown K D, Berridge M J
出版信息
Biochem J. 1984 Aug 15;222(1):269-72. doi: 10.1042/bj2220269.
Abstract
Swiss-mouse 3T3 cells permeabilized with saponin were used to study the specificity of the inositol trisphosphate-induced release of 45Ca2+ from their intracellular stores. Inositol 1,4,5-trisphosphate was the most potent compound studied (dose giving half-maximal effect 0.3 microM). 45Ca2+ was also released by inositol 2,4,5-trisphosphate, glycerophosphoinositol 4,5-bisphosphate and inositol 4,5-bisphosphate, with doses giving half-maximal effect of respectively 1.6 microM, 1.6 microM and 20 microM, but not by inositol 1,4-bisphosphate (50 microM). These data suggest that the trans-vicinal phosphates on the 4- and 5-positions are essential for the Ca2+-mobilizing effect of inositol trisphosphate, and that in addition there is a requirement for a phosphate group on the opposite side of the molecule, with a preference for the 1-position.
摘要
用皂角苷通透处理的瑞士小鼠3T3细胞用于研究肌醇三磷酸诱导细胞内储存的45Ca2+释放的特异性。肌醇1,4,5-三磷酸是所研究的最有效的化合物（产生半数最大效应的剂量为0.3微摩尔）。肌醇2,4,5-三磷酸、甘油磷酸肌醇4,5-二磷酸和肌醇4,5-二磷酸也能释放45Ca2+，产生半数最大效应的剂量分别为1.6微摩尔、1.6微摩尔和20微摩尔，但肌醇1,4-二磷酸（50微摩尔）不能。这些数据表明，4位和5位上的反式邻位磷酸对于肌醇三磷酸的钙动员效应至关重要，此外，分子另一侧还需要一个磷酸基团，优先在1位。
相似文献
1
Specificity of inositol trisphosphate-induced calcium release from permeabilized Swiss-mouse 3T3 cells.三磷酸肌醇诱导通透化的瑞士小鼠3T3细胞释放钙的特异性
Biochem J. 1984 Aug 15;222(1):269-72. doi: 10.1042/bj2220269.
2
Specificity of inositol phosphate-stimulated Ca2+ mobilization from Swiss-mouse 3T3 cells.来自瑞士小鼠3T3细胞的肌醇磷酸刺激的Ca2+动员的特异性。
Biochem J. 1986 Nov 15;240(1):301-4. doi: 10.1042/bj2400301.
3
Inositol trisphosphate formation and calcium mobilization in Swiss 3T3 cells in response to platelet-derived growth factor.瑞士3T3细胞中肌醇三磷酸的形成及钙动员对血小板衍生生长因子的响应
Biochem J. 1984 Aug 15;222(1):195-201. doi: 10.1042/bj2220195.
4
Calcium release from porcine thyroid microsomes by phosphatidylinositol 4,5-bisphosphate and inositol 1,4,5-trisphosphate.磷脂酰肌醇4,5-二磷酸和肌醇1,4,5-三磷酸诱导猪甲状腺微粒体释放钙
Endocrinology. 1987 Jun;120(6):2302-7. doi: 10.1210/endo-120-6-2302.
5
The digitonin-permeabilized pancreatic islet model. Effect of myo-inositol 1,4,5-trisphosphate on Ca2+ mobilization.洋地黄皂苷通透化处理的胰岛模型。肌醇1,4,5-三磷酸对钙离子动员的影响。
Biochem J. 1985 May 1;227(3):965-9. doi: 10.1042/bj2270965.
6
Actions of inositol phosphates on Ca2+ pools in guinea-pig hepatocytes.肌醇磷酸酯对豚鼠肝细胞中钙离子池的作用。
Biochem J. 1984 Dec 15;224(3):741-6. doi: 10.1042/bj2240741.
7
Inhibitory action of cyclic AMP on inositol 1,4,5-trisphosphate-induced Ca2+ release in saponin-permeabilized platelets.环磷酸腺苷对皂素通透化血小板中肌醇1,4,5-三磷酸诱导的钙离子释放的抑制作用
Biochim Biophys Acta. 1989 Sep 19;1013(2):190-3. doi: 10.1016/0167-4889(89)90048-7.
8
Inositol trisphosphate mobilizes intracellular calcium in permeabilized adrenal chromaffin cells.肌醇三磷酸在透化的肾上腺嗜铬细胞中动员细胞内钙。
J Neurochem. 1986 Feb;46(2):637-40. doi: 10.1111/j.1471-4159.1986.tb13014.x.
9
Inositol trisphosphate does not release Ca2+ from permeabilized cardiac myocytes and sarcoplasmic reticulum.肌醇三磷酸不能从透化的心肌细胞和肌浆网中释放钙离子。
FEBS Lett. 1985 Jun 17;185(2):328-32. doi: 10.1016/0014-5793(85)80932-7.
10
Modulation of intracellular Ca2+ in the parathyroid cell. Release of Ca2+ from non-mitochondrial pools by inositol trisphosphate.甲状旁腺细胞内钙离子的调节。三磷酸肌醇介导钙离子从非线粒体池释放。
FEBS Lett. 1985 Aug 19;188(1):141-4. doi: 10.1016/0014-5793(85)80891-7.
引用本文的文献
1
Production of fungal phytases in solid state fermentation and potential biotechnological applications.固态发酵生产真菌植酸酶及其潜在的生物技术应用。
World J Microbiol Biotechnol. 2023 Nov 27;40(1):22. doi: 10.1007/s11274-023-03783-1.
2
Inositol 1,3,4,5-tetrakisphosphate controls proapoptotic Bim gene expression and survival in B cells.肌醇1,3,4,5-四磷酸调控B细胞中促凋亡基因Bim的表达及细胞存活。
Proc Natl Acad Sci U S A. 2007 Aug 28;104(35):13978-83. doi: 10.1073/pnas.0704312104. Epub 2007 Aug 20.
3
Inositol trisphosphate receptor Ca2+ release channels.肌醇三磷酸受体钙离子释放通道
Physiol Rev. 2007 Apr;87(2):593-658. doi: 10.1152/physrev.00035.2006.
4
Functional properties of Drosophila inositol trisphosphate receptors.果蝇三磷酸肌醇受体的功能特性
Biochem J. 2001 Oct 15;359(Pt 2):435-41. doi: 10.1042/0264-6021:3590435.
5
ATP-dependent adenophostin activation of inositol 1,4,5-trisphosphate receptor channel gating: kinetic implications for the durations of calcium puffs in cells.三磷酸腺苷（ATP）依赖性腺嘌呤宿主素激活肌醇1,4,5-三磷酸受体通道门控：对细胞中钙瞬变持续时间的动力学影响
J Gen Physiol. 2001 Apr;117(4):299-314. doi: 10.1085/jgp.117.4.299.
6
7
Kinetics of elementary Ca2+ puffs evoked in Xenopus oocytes by different Ins(1,4,5)P3 receptor agonists.不同肌醇-1,4,5-三磷酸（Ins(1,4,5)P3）受体激动剂诱发非洲爪蟾卵母细胞中基本Ca2+ 钙瞬变的动力学
Biochem J. 1998 Sep 15;334 ( Pt 3)(Pt 3):505-9. doi: 10.1042/bj3340505.
8
Inositol 1,4,5-trisphosphate receptor subtypes differentially recognize regioisomers of D-myo-inositol 1,4,5-trisphosphate.肌醇1,4,5-三磷酸受体亚型对D-肌醇1,4,5-三磷酸的区域异构体具有不同的识别能力。
Biochem J. 1997 Nov 15;328 ( Pt 1)(Pt 1):93-8. doi: 10.1042/bj3280093.
9
Rapid kinetic measurements of 45Ca2+ mobilization reveal that Ins(2,4,5)P3 is a partial agonist at hepatic InsP3 receptors.对45Ca2+动员的快速动力学测量表明，肌醇(2,4,5)三磷酸（Ins(2,4,5)P3）是肝脏肌醇三磷酸受体的部分激动剂。
Biochem J. 1997 Feb 1;321 ( Pt 3)(Pt 3):573-6. doi: 10.1042/bj3210573.
10
A new inositol 1,4,5-trisphosphate binding protein similar to phospholipase C-delta 1.一种类似于磷脂酶C-δ1的新型肌醇1,4,5-三磷酸结合蛋白。
Biochem J. 1996 Jan 1;313 ( Pt 1)(Pt 1):319-25. doi: 10.1042/bj3130319.
本文引用的文献
1
Phosphoinositides. 5. The inositol lipids of ox brain.磷酸肌醇。5. 牛脑的肌醇脂质
Biochem J. 1963 Jul;88(1):125-31. doi: 10.1042/bj0880125.
2
Complete characterization of the myo-inositol polyphosphates from beef brain phosphoinositide.牛肉脑磷脂酰肌醇中肌醇多磷酸的完整表征。
J Biol Chem. 1961 Jul;236:1902-6.
3
Myo-inositol phosphates obtained by alkaline hydrolysis of beef brain phosphoinositide.通过牛肉脑磷酸肌醇碱性水解得到的肌醇磷酸酯。
J Biol Chem. 1961 Jan;236:54-60.
4
Alkaline O leads to N-transacylation. A new method for the quantitative deacylation of phospholipids.碱性O导致N-转酰基化。一种磷脂定量脱酰基化的新方法。
Biochem J. 1981 Apr 1;195(1):301-6. doi: 10.1042/bj1950301.
5
Inositol (1,4,5)trisphosphate-promoted Ca2+ release from microsomal fractions of rat liver.肌醇（1,4,5）三磷酸促进大鼠肝脏微粒体组分释放钙离子。
Biochem Biophys Res Commun. 1984 May 16;120(3):858-64. doi: 10.1016/s0006-291x(84)80186-2.
6
myo-Inositol 1,4,5-trisphosphate. A second messenger for the hormonal mobilization of intracellular Ca2+ in liver.肌醇1,4,5-三磷酸。肝脏中激素动员细胞内钙离子的第二信使。
J Biol Chem. 1984 Mar 10;259(5):3077-81.
7
Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate.1,4,5-三磷酸肌醇促使胰腺腺泡细胞非线粒体胞内钙库释放钙离子。
Nature. 1983;306(5938):67-9. doi: 10.1038/306067a0.
8
Rapid mobilization of Ca2+ from rat insulinoma microsomes by inositol-1,4,5-trisphosphate.肌醇-1,4,5-三磷酸促使大鼠胰岛素瘤微粒体中的钙离子快速动员。
Nature. 1984;309(5968):562-4. doi: 10.1038/309562a0.
9
The second messenger linking receptor activation to internal Ca release in liver.将受体激活与肝脏内部钙释放相联系的第二信使。
Nature. 1984;309(5963):63-6. doi: 10.1038/309063a0.
10
Thyroliberin stimulates rapid hydrolysis of phosphatidylinositol 4,5-bisphosphate by a phosphodiesterase in rat mammotropic pituitary cells. Evidence for an early Ca2+-independent action.促甲状腺素释放激素通过大鼠促乳腺垂体细胞中的磷酸二酯酶刺激磷脂酰肌醇4,5-二磷酸的快速水解。早期不依赖钙离子作用的证据。
Biochem J. 1983 Nov 15;216(2):287-94. doi: 10.1042/bj2160287.
Zotero 插件