Ghittori S, Imbriani M, Borlini F, Pezzagno G, Zadra P
Boll Soc Ital Biol Sper. 1984 Nov 30;60(11):2207-13.
The aim of this paper was to evaluate the lambda values of this group of solvents experimentally, by means of an analytical method which has already been used for other solvents. During our experiments we found that most acetates we tested (n-butyl-acetate; sec.butyl-acetate; ter-butyl-acetate; ethyl-acetate; amyl-acetate; methyl-acetate; n-propyl-acetate) were particularly unstable and hydrolyzed rapidly in alcohol and in the corresponding acid. The "in vitro" behaviour of these substances allow to draw the following conclusions: 1) For the acetates it is not possible to measure the values since the involved substances are chemically unstable in blood. 2) As it was shown by the half-life times of the "in vitro" acetates, the alcohols and the corresponding acids, are released rapidly in blood. 3) The biological monitoring of the acetates in expired air is not very significant; perhaps it is better to measure the corresponding alcohol in expired air. 4) In some cases the TLV of the alcohols is much lower than for the corresponding acetates; this finding and the rapid biotransformation we observed make us think that the TLV's proposed for some acetates are too high.
本文的目的是通过一种已用于其他溶剂的分析方法，对这组溶剂的λ值进行实验评估。在我们的实验过程中，我们发现所测试的大多数醋酸酯（醋酸正丁酯；醋酸仲丁酯；醋酸叔丁酯；醋酸乙酯；醋酸戊酯；醋酸甲酯；醋酸正丙酯）特别不稳定，在酒精和相应的酸中会迅速水解。这些物质的“体外”行为可得出以下结论：1）对于醋酸酯，由于相关物质在血液中化学不稳定，因此无法测量其值。2）正如“体外”醋酸酯的半衰期所示，醇类和相应的酸在血液中会迅速释放。3）对呼出气体中醋酸酯的生物监测意义不大；也许最好测量呼出气体中相应的醇。4）在某些情况下，醇的阈限值远低于相应的醋酸酯；这一发现以及我们观察到的快速生物转化使我们认为，为某些醋酸酯提出的阈限值过高。
