文献检索，用中文搜 PubMed

Suppr 超能文献

核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Groth G, Freundt K J

Institute of Pharmacology and Toxicology, Faculty of Clinical Medicine, University of Heidelberg, Mannheim, Germany.

Hum Exp Toxicol. 1994 Jul;13(7):478-80. doi: 10.1177/096032719401300705.

A continuous 5 h-exposure to approximately 440 ppm tert-butyl acetate in air (via a tracheal canule) resulted in continuously increasing concentrations of tert-butyl acetate and tert-butyl alcohol (metabolite of tert-butyl acetate) in the blood of rats. 2. This accumulation of tert-butyl acetate and tert-butyl alcohol was reproduced during a continuous exposure to about 900 ppm tert-butyl acetate in air over a period of 4 h and 15 min. After the inhalation approximately 50% of the blood level of tert-butyl acetate decreased within 45 min, but that of tert-butyl alcohol remained unchanged at a high level. 3. The accumulation of tert-butyl acetate and tert-butyl alcohol should be relevant for the health risk assessment at the workside.

通过气管插管让大鼠在空气中持续暴露于约440 ppm乙酸叔丁酯5小时，导致大鼠血液中乙酸叔丁酯及其代谢产物叔丁醇的浓度持续上升。2. 在空气中约900 ppm乙酸叔丁酯持续暴露4小时15分钟期间，再现了乙酸叔丁酯和叔丁醇的这种蓄积情况。吸入后，乙酸叔丁酯血液水平约50%在45分钟内下降，但叔丁醇的血液水平在高水平保持不变。3. 乙酸叔丁酯和叔丁醇的蓄积对于工作场所的健康风险评估应具有相关性。

Groth G, Freundt K J

Institute of Pharmacology and Toxicology, Faculty of Clinical Medicine, University of Heidelberg, Mannheim, Germany.

Hum Exp Toxicol. 1994 Jul;13(7):478-80. doi: 10.1177/096032719401300705.

A continuous 5 h-exposure to approximately 440 ppm tert-butyl acetate in air (via a tracheal canule) resulted in continuously increasing concentrations of tert-butyl acetate and tert-butyl alcohol (metabolite of tert-butyl acetate) in the blood of rats. 2. This accumulation of tert-butyl acetate and tert-butyl alcohol was reproduced during a continuous exposure to about 900 ppm tert-butyl acetate in air over a period of 4 h and 15 min. After the inhalation approximately 50% of the blood level of tert-butyl acetate decreased within 45 min, but that of tert-butyl alcohol remained unchanged at a high level. 3. The accumulation of tert-butyl acetate and tert-butyl alcohol should be relevant for the health risk assessment at the workside.

通过气管插管让大鼠在空气中持续暴露于约440 ppm乙酸叔丁酯5小时，导致大鼠血液中乙酸叔丁酯及其代谢产物叔丁醇的浓度持续上升。2. 在空气中约900 ppm乙酸叔丁酯持续暴露4小时15分钟期间，再现了乙酸叔丁酯和叔丁醇的这种蓄积情况。吸入后，乙酸叔丁酯血液水平约50%在45分钟内下降，但叔丁醇的血液水平在高水平保持不变。3. 乙酸叔丁酯和叔丁醇的蓄积对于工作场所的健康风险评估应具有相关性。