Ziegler R, Raue F
Biomed Pharmacother. 1984;38(5):245-51.
Radioimmunoassay systems of different characteristics are available for routine determination of human calcitonin (hCT). The purity and calcitonin content of the used standards has to be observed, different antisera may yield discrepant absolute values from the same plasma samples. HCT measurements permit blood level control during treatment with this hormone. In most thyroidectomized patients hCT is not measurable--it is supposed that there is no relevant extrathyroidal calcitonin production in man. HCT RIA systems also recognize rat calcitonin. In this species, chronic hypercalcemia first leads to increased calcitonin secretion which is soon followed by a decrease. Presumably, this fall reflects down-regulation of calcitonin secretion which is more a calcium conserving than an anti-hypercalcemic hormone.
有多种不同特性的放射免疫分析系统可用于常规检测人降钙素（hCT）。必须注意所用标准品的纯度和降钙素含量，不同的抗血清可能会从相同的血浆样本中得出不一致的绝对值。hCT测量有助于在使用这种激素治疗期间控制血药浓度。在大多数甲状腺切除的患者中，hCT无法测量——据推测，人类体内不存在相关的甲状腺外降钙素分泌。hCT放射免疫分析系统也能识别大鼠降钙素。在该物种中，慢性高钙血症首先会导致降钙素分泌增加，随后很快就会下降。据推测，这种下降反映了降钙素分泌的下调，降钙素更多的是一种保钙激素而非抗高钙血症激素。
