Apple D J, Craythorn J M, Reidy J J, Steinmetz R L, Brady S E, Bohart W A
Can J Ophthalmol. 1984 Dec;19(7):320-5.
A 47-year-old woman who had had a flat, hyperpigmented lesion of the optic disc and juxtapapillary choroid for at least 17 years experienced acute visual loss. This was caused by rapid growth of a pigmented tumour emanating from the original lesion. Histopathological examination of the enucleated globe revealed a large malignant melanoma originating from a melanocytoma (magnocellular nevus) within the optic nerve and peripapillary choroid. This case represents a very rare instance of malignant transformation of a normally benign tumour.
一名47岁女性，其视盘和视乳头旁脉络膜有扁平、色素沉着病变至少17年，出现急性视力丧失。这是由源自原病变的色素性肿瘤快速生长所致。摘除眼球的组织病理学检查显示，一个大的恶性黑色素瘤起源于视神经和视乳头周围脉络膜内的黑素细胞瘤（大细胞痣）。该病例代表了一种非常罕见的正常良性肿瘤恶变情况。
