Horton P, Gerster J C
Clin Rheumatol. 1984 Dec;3(4):493-9. doi: 10.1007/BF02031272.
Amongst 149 cases of reflex sympathetic dystrophy syndrome (RSDS), 25 (16.8%) were being treated with barbiturates at the time the RSDS symptoms began. This group is unusual by the frequent absence of provocative events (32%), a high number of diseased joints, bilaterality (76%), involvement of upper limbs (76%) and Dupuytren's disease (52%). Swift and complete recovery depends mostly on barbiturate withdrawal. These data support the idea that barbiturates may be the principal initiating event in some RSDS. Since unfavorable progress is seen with persistent use of barbiturates, this medication should be recognised early in the course of the disease in order to prevent severe sequels.
在149例反射性交感神经营养不良综合征（RSDS）患者中，有25例（16.8%）在RSDS症状开始时正在接受巴比妥类药物治疗。该组患者不同寻常之处在于，常有诱发事件缺失（32%）、患病关节数量多、双侧受累（76%）、上肢受累（76%）以及杜普伊特伦挛缩症（52%）。迅速且完全恢复主要取决于停用巴比妥类药物。这些数据支持这样一种观点，即巴比妥类药物可能是某些RSDS的主要起始因素。由于持续使用巴比妥类药物会出现不良进展，因此应在疾病过程中尽早识别这种药物，以预防严重后遗症。
