Falasca G F, Toly T M, Reginato A J, Schraeder P L, O'Connor C R
Division of Rheumatology, Cooper Hospital/University Medical Center, UMDNJ-Robert Wood Johnson Medical School at Camden.
Epilepsia. 1994 Mar-Apr;35(2):394-9. doi: 10.1111/j.1528-1157.1994.tb02450.x.
Reflex sympathetic dystrophy syndrome (RSDS) complicating antiepileptic drug (AED) therapy is not well acknowledged in the neurologic literature. We report 4 patients with reflex sympathetic dystrophy that occurred while they were receiving AEDs. All patients had shoulder and hand involvement, which in 2 was bilateral, and 1 had ipsilateral foot involvement. Two patients did not respond to a change in AEDs, but all improved with a course of prednisone. One patient with phenobarbital (PB)-associated RSDS relapsed on inadvertent rechallenge with secobarbital. A review of the literature showed that several other fibrosing disorders are associated with AED administration, including Dupuytren's contractures, frozen shoulder, plantar and hand nodules, and Peyronie's disease. RSD associated with AEDs is important to recognize because it may result in permanent disability if treatment is delayed.
抗癫痫药物（AED）治疗并发的反射性交感神经营养不良综合征（RSDS）在神经学文献中并未得到充分认识。我们报告了4例在接受AED治疗时发生反射性交感神经营养不良的患者。所有患者均有肩部和手部受累，其中2例为双侧受累，1例同侧足部受累。2例患者对AED的更换无反应，但所有患者经泼尼松治疗后均有改善。1例与苯巴比妥（PB）相关的RSDS患者在无意中再次使用司可巴比妥后复发。文献回顾显示，其他几种纤维化疾病与AED的使用有关，包括掌腱膜挛缩症、肩周炎、足底和手部结节以及佩罗尼氏病。认识到与AED相关的RSD很重要，因为如果治疗延迟，可能会导致永久性残疾。
