van Loon L A, van Elsas P W, van Joost T, Davidson C L
Contact Dermatitis. 1984 Nov;11(5):294-7. doi: 10.1111/j.1600-0536.1984.tb01013.x.
17 subjects were tested epicutaneously with 22 materials, including Ni, Pd, Cr and Co. 5 subjects with a positive allergic skin reaction to Ni were tested with a pure metallic nickel plate 3 X 5 mm, which was attached to the buccal side of one lower premolar. These 5 subjects all developed local allergic contact stomatitis on the mucosa of the cheek adjacent to the metal plate. This was confirmed histologically. The same oral test with pure metallic palladium gave no reaction in subjects with a positive patch test. A control group gave no reactions to the metal plates. Allergic contact stomatitis was diagnosed with the help of both clinical and histological examinations.
17名受试者用包括镍、钯、铬和钴在内的22种材料进行了皮肤试验。对镍有阳性过敏皮肤反应的5名受试者用一块3×5毫米的纯金属镍板进行测试，该镍板附着在一颗下前磨牙的颊侧。这5名受试者在与金属板相邻的脸颊黏膜上均出现了局部过敏性接触性口炎。组织学检查证实了这一点。对斑贴试验呈阳性的受试者进行的纯金属钯口腔试验未产生反应。对照组对金属板无反应。通过临床和组织学检查诊断出过敏性接触性口炎。
