Pathogenesis of metabolic alterations in renal failure.

New knowledge and trends in research of renal failure have opened new vistas not only in understanding its pathogenesis, but also in developing its therapy. It has been, shown, however, that the knowledge accumulated, namely the characterization of so far unknown modulators is of importance also for the therapy of diseases of other organ systems. Moreover, the knowledge of receptors of competent endogenous regulators has created the conditions for synthesis of their analogues and thereby for development of agonists and antagonists. These are extraordinary significant trends, the development of which is desirable to be speeded up to the maximum.