Timbrell J A, Wright J M
Hum Toxicol. 1984 Dec;3(6):485-95. doi: 10.1177/096032718400300603.
The urinary metabolite profile of isoniazid has been studied in patients receiving the drug as therapy for tuberculosis and the profile in patients suffering liver damage due to isoniazid compared with that in control patients. There were no consistent differences between control patients and those suffering liver damage in the excretion of isoniazid metabolites. It may be that susceptibility to the hepatotoxicity of isoniazid is not due to metabolic differences, although a number of other possible explanations are discussed. It is not at present possible to predict which patients will be susceptible from metabolic studies.
已对接受异烟肼治疗结核病患者的尿液代谢物谱进行了研究，并将因异烟肼导致肝损伤患者的代谢物谱与对照患者的进行了比较。对照患者与肝损伤患者在异烟肼代谢物排泄方面没有一致的差异。异烟肼肝毒性的易感性可能并非由于代谢差异，不过文中讨论了一些其他可能的解释。目前通过代谢研究尚无法预测哪些患者会易感。
