Rey E, d'Athis P, Richard M O, Fillastre J P, Olive G
Int J Clin Pharmacol Ther Toxicol. 1984 Dec;22(12):648-52.
The pharmacokinetics of single intravenous doses of buflomedil were studied in nine patients with chronic renal failure. The mean buflomedil half-life was 5.38 h (range 1.78-11.8 h); the mean buflomedil total clearance was 11.8 l/h (range 2.67-37.2 l/h). Comparisons of buflomedil kinetic parameters between the uraemic patients and healthy subjects revealed significant decreases in the renal elimination percentage u, the renal clearance Clr; significant increase in elimination half-life from the central compartment and no significant differences in the other parameters. Chronic renal failure is associated with a significant alteration in buflomedil elimination. This study suggests to reduce the usual dosage to half its value in the renal disease.
对9例慢性肾衰竭患者进行了单次静脉注射丁咯地尔的药代动力学研究。丁咯地尔的平均半衰期为5.38小时（范围为1.78 - 11.8小时）；丁咯地尔的平均总清除率为11.8升/小时（范围为2.67 - 37.2升/小时）。尿毒症患者与健康受试者之间丁咯地尔动力学参数的比较显示，尿排泄率u、肾清除率Clr显著降低；中央室消除半衰期显著延长，其他参数无显著差异。慢性肾衰竭与丁咯地尔消除的显著改变有关。本研究建议在肾脏疾病中将常规剂量减半。
