Rey E, Barrier G, d'Athis P, de Lauture D, Richard M O, Lirzin J P, Sureau C, Olive G
Int J Clin Pharmacol Ther Toxicol. 1980 Oct;18(10):437-41.
Pharmacokinetics studies were conducted in 4 patients who received buflomedil 100 mg intravenously and in 3 volunteers who received buflomedil 450 mg per os. Buflomedil concentrations were determined by a gas liquid chromatography method. Buflomedil levels declined multiphasically with a mean clearance after intravenous administration of -0,034 (1 h-1 kg-1). The decline appeared to be monophasic after oral administration. In both cases the overall half-life is short, mean 2.07 hrs (range, 1,47-2,6 hrs).
对4例静脉注射100毫克丁咯地尔的患者和3例口服450毫克丁咯地尔的志愿者进行了药代动力学研究。丁咯地尔浓度通过气液色谱法测定。静脉给药后，丁咯地尔水平呈多相下降，平均清除率为-0.034（1小时-1千克-1）。口服给药后下降似乎为单相。两种情况下总体半衰期均较短，平均2.07小时（范围为1.47 - 2.6小时）。
