Ruffmann R, Welker R D, Saito T, Chirigos M A, Varesio L
J Immunopharmacol. 1984;6(4):291-304. doi: 10.3109/08923978409028605.
Intraperitoneal injection of PLA into C57BL/6 mice induced high levels of macrophage-mediated cytostatic activity. Maximal cytostatic activity was found 3 days after injection of 100 mg/kg of PLA. In contrast, natural killer cell activity was not affected by PLA. Thus, PLA selectively modulates macrophage activity without influencing NK activity.