Grijseels H, Crommelin D J, De Blaey C J
J Pharm Sci. 1984 Dec;73(12):1771-4. doi: 10.1002/jps.2600731228.
With the aid of rapidly dissolving sodium chloride particles, cubic pores were made in the surface of a theophylline tablet. The influence of the pores on the dissolution rate of the surface was investigated in a rotating disk apparatus. Like the drilled pores used in earlier studies, downstream on the surface they caused a turbulent flow regimen with the development of a trough due to enhanced erosion. The phenomenon of a critical pore diameter, discovered with single, drilled pores, seems to be applicable to the cubic pores investigated in this study, although a higher degree of surface coverage with pores caused complications, probably due to particles bordering one another and forming larger pores. The behavior of the porous surfaces at different rotation speeds was studied. Due to the presence of pores the laminar character of the boundary layer flow changes to turbulent, which induces locally an increased dissolution flux in the wake of a pore.
借助快速溶解的氯化钠颗粒，在茶碱片剂表面制造出立方孔。在旋转圆盘装置中研究了这些孔对表面溶解速率的影响。与早期研究中使用的钻孔一样，在片剂表面下游，这些孔由于侵蚀增强导致形成了一个槽，从而产生了湍流状态。在单一钻孔中发现的临界孔径现象似乎也适用于本研究中所研究的立方孔，尽管更高的孔表面覆盖率会引发一些复杂情况，这可能是由于颗粒相互毗邻并形成了更大的孔。研究了不同转速下多孔表面的行为。由于孔的存在，边界层流的层流特性转变为湍流，这在孔的尾流中局部诱导了更高的溶解通量。
