盐酸氯胍的直流极谱还原
DC polarographic reduction of chloroguanide hydrochloride.
作者信息
Vicente-Pedrós F, Tomás-Vert F, Vera-Sánchez J
出版信息
J Pharm Sci. 1984 Dec;73(12):1804-6. doi: 10.1002/jps.2600731236.
PMID:6527261
Abstract
Chloroguanide hydrochloride, an antimalarial drug, shows one well-defined DC polarographic wave in Britton-Robinson buffered media. In the pH range 3-9 the observed reduction wave is related to the reduction of the two azomethine centers on the monoprotonated biguanide group (BH+). The effects of pH and other experimental variables on the limiting current and half-wave potentials as well as the reduction mechanism are discussed.
摘要
盐酸氯胍是一种抗疟药物，在 Britton-Robinson 缓冲介质中显示出一个明确的直流极谱波。在pH值为3 - 9的范围内，观察到的还原波与单质子化双胍基团（BH+）上两个偶氮甲碱中心的还原有关。讨论了pH值和其他实验变量对极限电流和半波电位的影响以及还原机理。
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