DC polarographic reduction of chloroguanide hydrochloride.

Chloroguanide hydrochloride, an antimalarial drug, shows one well-defined DC polarographic wave in Britton-Robinson buffered media. In the pH range 3-9 the observed reduction wave is related to the reduction of the two azomethine centers on the monoprotonated biguanide group (BH+). The effects of pH and other experimental variables on the limiting current and half-wave potentials as well as the reduction mechanism are discussed.