[3H]cocaine binding in brain is inhibited by Tris (hydroxymethyl) aminomethane.
作者信息
Reith M E, Meisler B E, Sershen H, Lajtha A
出版信息
J Neurosci Methods. 1984 Dec;12(2):151-4. doi: 10.1016/0165-0270(84)90014-1.
PMID:6527554
Abstract
High-affinity binding of [3H]cocaine to membranes of mouse cerebral cortex is inhibited by Tris (hydroxymethyl) aminomethane, the buffer commonly used in receptor binding assays. This inhibition is not due to an effect of ionic strength in general. Comparison of binding in Tris buffer with that in sodium phosphate buffer indicates a more than 4-fold higher Kd in the former buffer, with no differences in the Bmax values.
摘要
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