De Witte P
Neuropsychobiology. 1984;12(2-3):73-7. doi: 10.1159/000118113.
Male Wistar rats were able to drink water and different percentages of ethyl alcohol in a free-choice paradigm. Our results showed a clear-cut preference for 2 and 3% ethanol concentration. Addition of quinine in both drinking bottles increased preference for alcohol, while dilution of saccharin in both bottles totally suppressed this preference for the alcohol bottle. In this alcohol-water choice procedure, naloxone decreased the amount of alcohol intake without altering the amount drunk from the water bottle. This decrease was independent of the palatable or nonpalatable substances added to alcohol and also independent of the percentage of alcohol. Interpretation was done in terms of action of naloxone on the rewarding property of alcohol, or in terms of satiety mechanism for alcohol regulated by naloxone.
雄性Wistar大鼠能够在自由选择模式下饮用清水和不同百分比的乙醇。我们的结果显示，它们明显偏好2%和3%的乙醇浓度。在两个饮水瓶中添加奎宁会增加对酒精的偏好，而在两个瓶子中稀释糖精则完全抑制了对酒精瓶的这种偏好。在这种酒精-水选择程序中，纳洛酮减少了酒精摄入量，而不改变从水瓶中饮用的水量。这种减少与添加到酒精中的可口或不可口物质无关，也与酒精的百分比无关。这一结果可从纳洛酮对酒精奖赏特性的作用来解释，或者从纳洛酮调节的酒精饱腹感机制来解释。
