Sandi C, Borrell J, Guaza C
Department of Psychobiology, Cajal Institute, Madrid, Spain.
Psychopharmacology (Berl). 1990;100(3):350-4. doi: 10.1007/BF02244605.
The effects of subcutaneous administration of leu-enkephalin (LEU-E) (10, 100 and 300 micrograms/kg) and LEU-E (100 micrograms/kg) plus naloxone (2.5 mg/kg) on ethanol preference and fluid intake have been investigated in rats. Under our procedural conditions, rats develop ethanol preference through forced ethanol drinking (conditioning session). Preconditioning administration of LEU-E induced a reduction of later ethanol preference. Post-conditioning administration of LEU-E (10 and 100 micrograms/kg) also attenuated the development of ethanol preference. NX antagonized the effects of LEU-E on ethanol preference and fluid consumption in the two experimental procedures used, indicating an involvement of opioid receptors in the LEU-E-induced impairment of the acquisition of ethanol preference.
已在大鼠中研究了皮下注射亮氨酸脑啡肽（LEU-E）（10、100和300微克/千克）以及LEU-E（100微克/千克）加纳洛酮（2.5毫克/千克）对乙醇偏好和液体摄入量的影响。在我们的实验条件下，大鼠通过强制饮用乙醇（条件训练期）形成乙醇偏好。预处理给予LEU-E可降低随后的乙醇偏好。条件训练后给予LEU-E（10和100微克/千克）也减弱了乙醇偏好的形成。在所用的两种实验程序中，纳洛酮拮抗了LEU-E对乙醇偏好和液体消耗的影响，表明阿片受体参与了LEU-E诱导的乙醇偏好获得受损。
