Lipid peroxides in human articular cartilage.

The hypothesis that increased generation of lipid peroxides (LP) causes articular cartilage damage in older patients and in those with osteoarthritis was tested by directly measuring LP tissue levels in various layers of human articular cartilage. The LP content was significantly greater in the superficial than in the deeper portion of the cartilage, but lower in cartilage than in liver, kidney, adrenal glands and synovium. When LP were related to the total lipid content of these tissues, a high peroxide per lipid ratio was obtained for articular cartilage. The relevance of these findings to the mechanism of cartilage fibrillation is discussed.