Ozerova I N, Gerasimova E N, Maĭ F T, Kurdanov Kh A
Vopr Med Khim. 1984 Sep-Oct;30(5):118-23.
An esterifying activity of blood plasma (lecithin-cholesterol-acyl transferase, LCAT) was decreased in men with ischemic heart disease (IHD) and coronary atherosclerosis as compared with patients without any symptoms of IHD; the decrease of the activity was most distinct in patients with low level of cholesterol in high density lipoproteins (HDL) and with hyperlipidemia. In these patients phospholipid composition of HDL subfractions was altered: a decrease in the lecithin ratio, increase in the content of sphingomyelin and corresponding decrease in the ratio lecithin/sphingomyelin. Decrease in content of HDL cholesterol and in concentration of apo A-I in blood, plasma, alterations in phospholipid composition of HDL subfractions and in the rate of fatty acids unsaturation of HDL phospholipids in the patients with IHD were considered as factors responsible for the decrease of LCAT activity, which may aggravate the atherosclerotic impairment of arteries.
与无缺血性心脏病（IHD）症状的患者相比，患有缺血性心脏病和冠状动脉粥样硬化的男性血浆酯化活性（卵磷脂胆固醇酰基转移酶，LCAT）降低；在高密度脂蛋白（HDL）胆固醇水平低和患有高脂血症的患者中，该活性的降低最为明显。在这些患者中，HDL亚组分的磷脂组成发生了改变：卵磷脂比例降低，鞘磷脂含量增加，相应地卵磷脂/鞘磷脂比例降低。IHD患者HDL胆固醇含量降低、血液和血浆中载脂蛋白A-I浓度降低、HDL亚组分磷脂组成改变以及HDL磷脂脂肪酸不饱和度降低被认为是导致LCAT活性降低的因素，这可能会加重动脉的动脉粥样硬化损伤。
