Sensing H
Z Gesamte Inn Med. 1984 Dec 1;39(23):582-5.
In 24 persons with healthy liver and 44 patients with chronic hepatopathies of different degree of severity (23 women and 16 men with chronic active hepatitis as well as 4 women and 1 man with unspecific degenerative damage of the liver parenchyma) in the C-bile conjugated bile acids were qualitatively differentiated. In contrast to persons with healthy liver in chronic hepatopathies apart from conjugated bile acids free bile acids appeared. The conjugation of the bile acids with taurine was proved in greater frequency than the glycine conjugation. Parallel to the degree of severity of the hepatopathy particularly the proportion of the taurine-conjugated dihydroxycholan acids increased, among which the tauro-chenodesoxycholic acid prevailed. The conjugation of the bile acids with glycine also in chronic hepatopathies remained longest in the fraction of the trihydroxycholan acids. The examinations show that the qualitative proof of the conjugated bile acids in the bile gives an additional information for the diagnostic estimation of the chronic hepatopathies.
对24例肝脏健康者以及44例不同严重程度的慢性肝病患者（23名女性和16名男性患有慢性活动性肝炎，4名女性和1名男性患有肝实质非特异性退行性损害）的结合型胆汁酸进行了定性鉴别。与肝脏健康者相比，慢性肝病患者除结合型胆汁酸外还出现了游离胆汁酸。已证实胆汁酸与牛磺酸的结合频率高于与甘氨酸的结合。与肝病严重程度平行，尤其是牛磺酸结合的二羟基胆酸比例增加，其中牛磺鹅去氧胆酸占优势。在慢性肝病中，胆汁酸与甘氨酸的结合在三羟基胆酸部分中保留的时间也最长。检查表明，胆汁中结合型胆汁酸的定性检测为慢性肝病的诊断评估提供了额外信息。
