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[致命性秋水仙碱中毒]

[Fatal colchicine poisoning].

作者信息

Harzer K

出版信息

Z Rechtsmed. 1984;93(3):181-5. doi: 10.1007/BF00200448.

DOI:10.1007/BF00200448
PMID:6528748
Abstract

In two cases, after i.v. injections of colchicine serum concentrations of 170 ng/ml and 240 ng/ml were found before death. Colchicine was extracted from serum with the aid of Extrelut extraction columns and analysed using HPLC. Urine was also analysed and the findings were confirmed by drawing a UV-curve for colchicine using the stop-flow method. In one case, colchicine was still detectable in urine 10 days after injection.

摘要

在两起案例中,静脉注射秋水仙碱后,死亡前血清浓度分别为170纳克/毫升和240纳克/毫升。借助于埃克斯特路特萃取柱从血清中提取秋水仙碱,并使用高效液相色谱法进行分析。同时也对尿液进行了分析,并通过停流法绘制秋水仙碱的紫外曲线来证实分析结果。在其中一个案例中,注射10天后尿液中仍可检测到秋水仙碱。

相似文献

1
[Fatal colchicine poisoning].[致命性秋水仙碱中毒]
Z Rechtsmed. 1984;93(3):181-5. doi: 10.1007/BF00200448.
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本文引用的文献

1
A fatal overdose with colchicine.秋水仙碱致死性过量服用。
J Anal Toxicol. 1980 May-Jun;4(3):153-5. doi: 10.1093/jat/4.3.153.
2
Colchicine poisoning as a mode of suicide.
J Forensic Sci. 1982 Oct;27(4):944-7.
3
Colchicine plasma levels. Implications as to pharmacology and mechanism of action.秋水仙碱血浆水平。对药理学及作用机制的启示。
Am J Med. 1970 Apr;48(4):443-8. doi: 10.1016/0002-9343(70)90043-4.
4
Plasma levels of colchicine after oral administration of a single dose.单次口服秋水仙碱后的血浆水平。
Metabolism. 1973 May;22(5):749-53. doi: 10.1016/0026-0495(73)90247-3.
5
[Determination of colchicine in biological fluids].[生物体液中秋水仙碱的测定]
Ann Biol Clin (Paris). 1976;34(6):393-401.
6
Evaluation of column extraction: a new procedure for the analysis of drugs in body fluids.
Forensic Sci. 1976 Mar-Apr;7(2):131-40. doi: 10.1016/0300-9432(76)90029-7.
7
Estimation of colchicine in a poisoned patient by using high performance liquid chromatography.
Clin Toxicol. 1979 Apr;14(4):375-81. doi: 10.3109/15563657909010599.