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秋水仙碱中毒：一例致命病例报告及用于体液和组织分析的高效液相色谱法介绍

Colchicine poisoning: report of a fatal case and presentation of an HPLC procedure for body fluid and tissue analyses.

作者信息

Kintz P, Jamey C, Tracqui A, Mangin P

机构信息

Institut de Médecine Légale, Strasbourg, France.

出版信息

J Anal Toxicol. 1997 Jan-Feb;21(1):70-2. doi: 10.1093/jat/21.1.70.

DOI:10.1093/jat/21.1.70
PMID:9013296
Abstract

A case involving a suicidal overdose resulting from the ingestion of colchicine tablets is presented. The drug was quantitated using liquid chromatography. The femoral blood level was 62 ng/mL, and the maximum concentration found in bile was 2921 ng/mL. Therefore, bile appears to be the sample of choice for toxicological analysis when a poisoning case involving colchicine is suspected.

摘要

本文介绍了一例因服用秋水仙碱片导致自杀性过量服药的病例。使用液相色谱法对该药物进行定量分析。股静脉血中药物浓度为62纳克/毫升，胆汁中发现的最高浓度为2921纳克/毫升。因此，当怀疑发生涉及秋水仙碱的中毒病例时，胆汁似乎是毒理学分析的首选样本。

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