Belcheva I, Stoytchev T
Acta Physiol Pharmacol Bulg. 1984;10(3):29-35.
The acute and subchronic toxicity (30 days) of N-aminomethylmorpholine-3,3-diethyl-2,4-pyridinedione (DKMM) and N-aminomethyl-piperazine-3,3-diethyl-2,4-pyridinedione (DKMP) was studied. The two compounds were found to have low acute toxicity. No changes are found in the haematological, urological and biochemical parameters, as well as in the histological tests of liver and parts of the cerebrum, after subchronic treatment with doses 150 there is an increase in GOT, GPT and the acid phosphatase. These results also correlate with the histological studies of the liver. The results of the acute toxicity show that DKMM and DKMP are weakly toxic substances (LD50 above 1500 mg/kg). Under conditions of the subchronic experiment the substances were tolerated very well by the animals, without causing lethality and essential toxicological changes in the organs studied.
研究了N-氨甲基吗啉-3,3-二乙基-2,4-吡啶二酮（DKMM）和N-氨甲基哌嗪-3,3-二乙基-2,4-吡啶二酮（DKMP）的急性和亚慢性毒性（30天）。发现这两种化合物急性毒性较低。亚慢性给予150剂量后，血液学、泌尿学和生化参数以及肝脏和部分大脑的组织学检查均未发现变化，但谷草转氨酶（GOT）、谷丙转氨酶（GPT）和酸性磷酸酶有所升高。这些结果也与肝脏的组织学研究相关。急性毒性结果表明，DKMM和DKMP是低毒物质（半数致死量高于1500毫克/千克）。在亚慢性实验条件下，动物对这些物质耐受性良好，未导致所研究器官的致死性和基本毒理学变化。
