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出血性慢性放射性膀胱炎——盆腔恶性肿瘤治疗后。

Haemorrhagic chronic radiation cystitis--following treatment of pelvic malignancies.

作者信息

Pillay P K, Teh M, Chua E J, Tan E C, Tung K H, Foo K T

出版信息

Ann Acad Med Singap. 1984 Oct;13(4):634-8.

PMID:6529148
Abstract

Haemorrhagic chronic radiation cystitis is not an uncommon clinical entity, and should be suspected in patients with painless gross haematuria who have a past history of radiotherapy to the pelvic region. A series of 29 patients with haemorrhagic chronic radiation cystitis were managed in the University Department of Surgery, Singapore General Hospital over a 5 years period from 1979 to 1983. Cystodiathermy was the mainstay of treatment and was successful in controlling haematuria in 27 patients. Two patients developed uncontrolled haematuria, urinary tract infection, septicaemia and died giving mortality of 6.9%. Excellent control of haemorrhage can be obtained with cystodiathermy in the majority of patients. Intravesical instillation of steroid or silver nitrate is used for the more intractable cases, after cystodiathermy. Urinary diversion with or without cystectomy are desperate measures to salvage the severe case and mortality is high.

摘要

出血性慢性放射性膀胱炎是一种并不罕见的临床病症,对于有盆腔放疗史且有无痛性肉眼血尿的患者应怀疑此病。1979年至1983年的5年间,新加坡中央医院外科收治了一系列29例出血性慢性放射性膀胱炎患者。膀胱电灼术是主要的治疗方法,27例患者通过该方法成功控制了血尿。2例患者出现无法控制的血尿、尿路感染、败血症并死亡,死亡率为6.9%。大多数患者通过膀胱电灼术可实现对出血的良好控制。对于膀胱电灼术后更棘手的病例,可采用膀胱内灌注类固醇或硝酸银。有或没有膀胱切除术的尿流改道术是挽救重症患者的极端措施,且死亡率很高。

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引用本文的文献

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Intravesical silver nitrate for refractory hemorrhagic cystitis.膀胱内注射硝酸银治疗难治性出血性膀胱炎。
Turk J Urol. 2016 Sep;42(3):197-201. doi: 10.5152/tud.2016.38445.
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Chemical- and radiation-induced haemorrhagic cystitis: current treatments and challenges.化学和辐射诱导的出血性膀胱炎:当前的治疗方法和挑战。
BJU Int. 2013 Nov;112(7):885-97. doi: 10.1111/bju.12291.
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Non-surgical interventions for late radiation cystitis in patients who have received radical radiotherapy to the pelvis.针对盆腔接受根治性放疗患者的晚期放射性膀胱炎的非手术干预措施。
Cochrane Database Syst Rev. 2002;2002(3):CD001773. doi: 10.1002/14651858.CD001773.