Myren J, Lövland B, Larssen S E, Larsen S
Ann Gastroenterol Hepatol (Paris). 1984 May-Jun;20(3):117-23.
In the present multicentre double blind study of 428 patients with the irritable bowel syndrome a significant beneficial effect was found on abdominal pain, nausea, sleeplessness and depression by using 50 mg of the antidepressive drug, trimipramine, in the evening, as well as 10 mg three times daily. A significant effect was also recorded for the total score of wellbeing during the treatment period of 6 weeks. No side effects were recorded except tiredness in the morning in some patients during the first two weeks.
在这项针对428例肠易激综合征患者的多中心双盲研究中，发现晚上服用50毫克抗抑郁药物三甲丙咪嗪以及每日三次服用10毫克，对腹痛、恶心、失眠和抑郁有显著的有益效果。在为期6周的治疗期间，整体健康状况总分也有显著改善。除了部分患者在前两周出现早晨疲倦外，未记录到其他副作用。
