Pattee P L, Thompson W G
University of Ottawa, Ottawa Civic Hospital, Ontario, Canada.
Drugs. 1992 Aug;44(2):200-6. doi: 10.2165/00003495-199244020-00004.
Irritable bowel syndrome (IBS) is defined as a functional bowel disorder in which abdominal pain is associated with defecation or a change in bowel habit, and with features of disordered defecation and distension. The irritable bowel syndrome occurs in 10 to 20% of people worldwide and is very commonly encountered in clinical practice. This has encouraged the pharmaceutical industry to search for effective drug therapy. So far, a universally effective agent has not been found, and since this is a chronic, benign disorder, beginning in youth, long term drug use should be avoided. Nevertheless, if a specific IBS symptom, such as constipation or abdominal pain dominates, a specific drug may be helpful. However, tests and treatment should be minimised or even avoided in order to do no harm. A largely nonpharmaceutical approach to IBS should be taken. This approach employs drugs sparingly and then only targeted at specific and resistant symptoms.
肠易激综合征（IBS）被定义为一种功能性肠道疾病，其腹痛与排便或排便习惯改变相关，并伴有排便紊乱和腹胀的特征。肠易激综合征在全球10%至20%的人群中发生，在临床实践中非常常见。这促使制药行业寻找有效的药物治疗方法。到目前为止，尚未找到一种普遍有效的药物，而且由于这是一种始于青年时期的慢性良性疾病，应避免长期用药。然而，如果特定的肠易激综合征症状，如便秘或腹痛占主导，特定药物可能会有所帮助。然而，为了避免造成伤害，应尽量减少甚至避免检查和治疗。对于肠易激综合征应采取一种主要是非药物的方法。这种方法谨慎使用药物，然后仅针对特定的顽固症状。
