氟比洛芬与单剂量阿替洛尔和普萘洛尔的相互作用。
Flurbiprofen interaction with single doses of atenolol and propranolol.
作者信息
Webster J, Petrie J C, McLean I, Hawksworth G M
出版信息
Br J Clin Pharmacol. 1984 Dec;18(6):861-6. doi: 10.1111/j.1365-2125.1984.tb02556.x.
Abstract
In patients with mild hypertension, flurbiprofen in a dose of 100 mg daily for 7 days attenuated the hypotensive effect of a single dose of propranolol 80 mg but not of atenolol 100 mg. The attenuation was not due to an effect on the pharmacokinetic profile of either propranolol or atenolol. An alternative explanation is required.
摘要
在轻度高血压患者中，每日服用100毫克氟比洛芬，持续7天，可减弱单次服用80毫克普萘洛尔的降压效果，但对单次服用100毫克阿替洛尔的降压效果无影响。这种减弱并非由于对普萘洛尔或阿替洛尔药代动力学特征的影响。需要另寻解释。
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本文引用的文献
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2
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Br J Clin Pharmacol. 1980 Jul;10(1):33-9. doi: 10.1111/j.1365-2125.1980.tb00499.x.
3
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5
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6
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