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癌症前体及其通过免疫系统刺激的调控。

Cancer precursors and their control by stimulation of the immune system.

作者信息

Rosenthal S R

出版信息

Biomed Pharmacother. 1984;38(9-10):429-33.

PMID:6529600
Abstract

BCG vaccination at birth according to our studies and those from Montreal, Austria, and Israel, lowers the mortality from leukemia and, in my studies, to all forms of cancer followed over a period of 20 years. It has been proposed by several studies that the lymphoreticulo-endothelial system detects and destroys neoantigens such as would be the case in remnant embryonic antigens. It follows that stimulation of the immune system would be desirable at birth to augment the removal of such neoantigens. There are numerous vaccines which stimulate the immune system, and BCG is among the foremost. I propose, therefore, that the mechanism of cancer mortality reduction in those BCG vaccinated at birth was at least in part due to the detection and destruction of embryonic cells or components thereof. To prove this theory, I recommend: Retrospective studies be done in those BCG vaccinated at birth and those not vaccinated for the incidence of cancer and leukemia over the years. Test cells, sera, and urine of those BCG vaccinated and non-vaccinated for the presence of embryonic antigens or antibodies. BCG vaccinated individuals should have lower titers of fetal antigens or antibodies than the non-vaccinated. Examine the organs on post mortem of BCG vaccinated and non-vaccinated individuals who died from trauma for the presence of fetal antigens or antibodies.

摘要

根据我们的研究以及来自蒙特利尔、奥地利和以色列的研究,出生时接种卡介苗可降低白血病死亡率,在我的研究中,还可降低随访20年期间所有癌症的死亡率。多项研究表明,淋巴网状内皮系统能检测并破坏新抗原,就像在残留胚胎抗原的情况中一样。因此可以推断,出生时刺激免疫系统以增强此类新抗原的清除是可取的。有许多疫苗能刺激免疫系统,卡介苗是其中最重要的之一。所以我认为,出生时接种卡介苗降低癌症死亡率的机制至少部分是由于对胚胎细胞或其成分的检测和破坏。为证明这一理论,我建议:对出生时接种卡介苗和未接种卡介苗的人群进行回顾性研究,统计多年来癌症和白血病的发病率。检测接种卡介苗和未接种卡介苗人群的细胞、血清和尿液,查看是否存在胚胎抗原或抗体。接种卡介苗的个体胎儿抗原或抗体的滴度应低于未接种者。对因创伤死亡的接种卡介苗和未接种卡介苗个体进行尸检,检查器官中是否存在胎儿抗原或抗体。

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