Ambrosch F, Wiedermann G, Krepler P
Dev Biol Stand. 1986;58 ( Pt A):419-24.
In the situation of low and decreasing risk of tuberculosis the possible non specific effect of BCG vaccination against leukemia becomes more and more important. To answer this question several studies using epidemiological and clinical data of children up to 5 years were performed in Austria. The following parameters which might be influenced by a possible protective effect of BCG vaccination were checked: leukemia mortality, case fatality, age of manifestation, frequency of different kinds of leukemia and the distribution of tuberculin reactions in leukemic and non leukemic children. All these parameters showed significant differences between vaccinated and non vaccinated leukemic and non leukemic children respectively making a protective effect of BCG vaccination against leukemia highly probable.
在结核病风险较低且呈下降趋势的情况下，卡介苗接种对白血病可能的非特异性作用变得越来越重要。为回答这一问题，奥地利利用5岁以下儿童的流行病学和临床数据开展了多项研究。对可能受卡介苗接种潜在保护作用影响的以下参数进行了核查：白血病死亡率、病死率、发病年龄、不同类型白血病的发病率以及白血病患儿和非白血病患儿结核菌素反应的分布情况。所有这些参数在接种和未接种疫苗的白血病患儿及非白血病患儿之间均显示出显著差异，这使得卡介苗接种对白血病具有保护作用的可能性很大。
