烟酰胺腺嘌呤二核苷酸磷酸氧化还原状态与线粒体钙离子外流：一个有争议的问题。
NADP redox state and mitochondrial Ca2+ efflux: a controversial issue.
作者信息
Vercesi A E, Pereira-da-Silva L
出版信息
Braz J Med Biol Res. 1984;17(3-4):353-6.
PMID:6529616
Abstract
It has been shown that Ca2+ efflux from respiring liver mitochondria is promoted by the oxidized steady state of mitochondrial pyridine nucleotides (NAD(P)), whereas Ca2+ retention is favored by a more reduced state (Lehninger, A.L., Vercesi, A.E. and Bababunmi, E.A., Proceedings of the National Academy of Sciences USA, 75, 1690-1694, 1978). The physiological relevance and the molecular mechanism responsible for the process are controversial and are discussed here.
摘要
研究表明，线粒体吡啶核苷酸（NAD(P)）的氧化稳态可促进呼吸作用的肝脏线粒体中Ca2+外流，而Ca2+保留则更倾向于还原态（Lehninger, A.L., Vercesi, A.E.和Bababunmi, E.A.，《美国国家科学院院刊》，75, 1690 - 1694, 1978）。该过程的生理相关性和分子机制存在争议，本文将对此进行讨论。
相似文献
1
NADP redox state and mitochondrial Ca2+ efflux: a controversial issue.烟酰胺腺嘌呤二核苷酸磷酸氧化还原状态与线粒体钙离子外流：一个有争议的问题。
Braz J Med Biol Res. 1984;17(3-4):353-6.
2
The participation of NADP, the transmembrane potential and the energy-linked NAD(P) transhydrogenase in the process of Ca2+ efflux from rat liver mitochondria.烟酰胺腺嘌呤二核苷酸磷酸（NADP）、跨膜电位以及能量偶联的烟酰胺腺嘌呤二核苷酸（磷酸）转氢酶在大鼠肝脏线粒体钙离子外流过程中的作用。
Arch Biochem Biophys. 1987 Jan;252(1):171-8. doi: 10.1016/0003-9861(87)90021-x.
3
Hepatic calcium efflux during cytochrome P-450-dependent drug oxidations at the endoplasmic reticulum in intact liver.完整肝脏内质网中细胞色素P-450依赖的药物氧化过程中的肝脏钙外流。
Proc Natl Acad Sci U S A. 1981 Jun;78(6):3358-62. doi: 10.1073/pnas.78.6.3358.
4
The metabolism of menadione impairs the ability of rat liver mitochondria to take up and retain calcium.甲萘醌的代谢会损害大鼠肝脏线粒体摄取和保留钙的能力。
J Biol Chem. 1982 Oct 10;257(19):11558-62.
5
Regulation of Ca2+ release from mitochondria by the oxidation-reduction state of pyridine nucleotides.吡啶核苷酸氧化还原状态对线粒体Ca2+释放的调节。
Proc Natl Acad Sci U S A. 1978 Apr;75(4):1690-4. doi: 10.1073/pnas.75.4.1690.
6
N-acetyl-p-benzoquinone imine induces Ca2+ release from mitochondria by stimulating pyridine nucleotide hydrolysis.N-乙酰对苯醌亚胺通过刺激吡啶核苷酸水解诱导线粒体释放钙离子。
J Biol Chem. 1992 Jan 15;267(2):804-9.
7
t-Butylhydroperoxide-induced Ca2+ efflux from liver mitochondria in the presence of physiological concentrations of Mg2+ and ATP.在生理浓度的镁离子（Mg2+）和三磷酸腺苷（ATP）存在的情况下，叔丁基过氧化氢诱导肝线粒体中的钙离子（Ca2+）外流。
Biochim Biophys Acta. 1986 Jun 10;850(1):41-8. doi: 10.1016/0005-2728(86)90006-x.
8
Hydroperoxide effects on redox state of pyridine nucleotides and Ca2+ retention by mitochondria.
Methods Enzymol. 1984;105:435-41. doi: 10.1016/s0076-6879(84)05061-8.
9
Influence of the redox state of pyridine nucleotides on mitochondrial sulfhydryl groups and permeability transition.吡啶核苷酸的氧化还原状态对线粒体巯基和通透性转变的影响。
Arch Biochem Biophys. 1997 Jun 1;342(1):22-8. doi: 10.1006/abbi.1997.9986.
10
Hydroperoxide-stimulated release of calcium from rat liver and AS-30D hepatoma mitochondria.过氧化氢刺激大鼠肝脏和AS - 30D肝癌线粒体释放钙。
Cancer Res. 1986 Jul;46(7):3459-63.
Zotero 插件