Faré J C, Guesnon P, Helouis J J, Normand S, André J L, Duvaldestin P
Cah Anesthesiol. 1984 May-Jun;32(4):303-6.
10 mg of diazepam in fat emulsion was given for premedication intramuscularly to 106 patients. In 53% of the cases patients were well sedated, 33% were apprehensive, 14% anxious. Pain related to the injection was complained of by 4 patients. Plasma concentration of diazepam at induction (60 minutes after the injection) was 130 ng/ml. Compared to diazepam in propylene glycol, pain at the injection side was less frequent while the level of sedation and the plasma concentration of diazepam were similar.
将10毫克地西泮加入脂肪乳剂中，对106例患者进行术前肌内注射。53%的患者镇静效果良好，33%的患者感到忧虑，14%的患者焦虑。4例患者主诉注射部位疼痛。诱导时（注射后60分钟）地西泮的血浆浓度为130纳克/毫升。与丙二醇中的地西泮相比，注射部位的疼痛发生率较低，而镇静水平和地西泮的血浆浓度相似。
