Cuchet D, Vagny C, Rochette A, Jullien Y, du Cailar J
Cah Anesthesiol. 1984 Dec;32(8):661-4.
Two groups of 20 women randomly distributed underwent general anaesthesia based on dextromoramide and droperidol. Midazolam was given 0.2 mg X kg-1 in the first group, 0.4 mg X kg-1 in the second. Induction was considered satisfactory in more than 90 p. cent of patients in both groups (NS). Midazolam produced a decrease of systolic blood pressure of 9 mm Hg in group I (p less than 0,001) and 11 mm Hg in group II (p less than 0,001) as well as a decrease in diastolic blood pressure of 5 mm Hg (p less than 0,025) and 7 mm Hg (p less than 0,005) respectively. Heart rate decreased significantly only in group II (by 4 c X mn-1, p less than 0,01). These alterations were similar in both groups and did not reach physiologic importance. Maintenance of anesthesia as well as recovery were uneventful in all cases. Higher doses of midazolam reduced only slightly the dose of the neuroleptic. Its is concluded that midazolam is a good induction agent neuroleptic-analgesic anaesthesia. The use of more than 0.2 mg X kg-1 is of no particular interest but is well tolerated.
两组各20名随机分配的女性接受了基于右吗拉胺和氟哌利多的全身麻醉。第一组给予咪达唑仑0.2mg×kg-1，第二组给予0.4mg×kg-1。两组中超过90%的患者诱导效果令人满意（无显著性差异）。咪达唑仑使第一组收缩压降低9mmHg（p<0.001），第二组降低11mmHg（p<0.001），同时舒张压分别降低5mmHg（p<0.025）和7mmHg（p<0.005）。仅第二组心率显著下降（降低4次/分钟，p<0.01）。两组的这些改变相似，且未达到生理重要性。所有病例的麻醉维持和恢复均顺利。较高剂量的咪达唑仑仅略微减少了抗精神病药物的剂量。结论是咪达唑仑是神经安定镇痛麻醉的良好诱导剂。使用超过0.2mg×kg-1没有特别意义，但耐受性良好。
